Έχει συνεργαστεί με το Ελληνικό Ινστιτούτο Pasteur, αρχικά στο πλαίσιο της διπλωματικής της εργασίας και στη συνέχεια ως βοηθός εργαστηρίου. Οι ερευνητικές της δραστηριότητες επικεντρώθηκαν, μεταξύ άλλων θεμάτων, στο μονοπάτι των κατεχολαμινών, στη ρύθμιση του μονοπατιού της αυτοφαγίας καθώς και στη συσχέτιση αυτών με τους ιούς FlaviviridaeShe has been working with the Hellenic Pasteur Institute, first as part of her thesis and then as a laboratory assistant. Her research activities focused on various topics, including the catecholamine pathway, the regulation of the autophagy pathway, and its association with Flaviviridae viruses. Since December 2023, she has been working at the Unit of Allergy and Clinical Immunology of the 2nd Pediatric Clinic of the University of Athens, where she is investigating new interventions in nut allergy by participating in the research project "Impact of the extrusion process on the allergenicity of foods".

Despoina has published the following papers in international scientific journals:

- L-Dopa Decarboxylase Modulates Autophagy in Hepatocytes and is Implicated in Dengue Virus-caused Inhibition of Autophagy Completion

- Significance of Catecholamine Biosynthetic/Metabolic Pathway in SARS-CoV-2 Infection and COVID-19 Severity

- Distribution of Hepatitis C Virus Genotypes among Chronic HCV Patients in Greece from 2004 to 2019: Association of Genotypes and Viral Load with Gender and Age

She has presented her studies in international and national conferences in the form of talks and posters.